All Strain, No Gain

Kinesin Motors: No Strain, No Gain

The processive movement of the dimeric motor protein kinesin 1 along microtubules requires communication between the two motor domains. Yildiz et al. (2008) now show that tension between the motor domains not only is necessary for normal processivity but also may be sufficient for motor motility under some conditions.

No pain - all gain: Advocating for improved paediatric pain management.

No strain, no gain: psychosocial predictors of physical activity across the adult lifespan.

BACKGROUND Physical activity is an essential ingredient in the recipe for successful aging, yet physical activity engagement declines with advancing age. METHODS In a national sample of 3848 participants aged 32 to 84 (55% women), we examined potential psychosocial moderators of the relationship between age and physical activity. RESULTS In a cross-sectional hierarchical multiple regression...

Plant neurobiology: no brain, no gain?

Amedeo Alpi, Nikolaus Amrhein, Adam Bertl, Michael R. Blatt, Eduardo Blumwald, Felice Cervone, Jack Dainty, Maria Ida De Michelis, Emanuel Epstein, Arthur W. Galston, Mary Helen M. Goldsmith, Chris Hawes, Rüdiger Hell, Alistair Hetherington, Herman Hofte, Gerd Juergens, Chris J. Leaver, Anna Moroni, Angus Murphy, Karl Oparka, Pierdomenico Perata, Hartmut Quader, Thomas Rausch, Christophe Ritzen...

No static at all.

Permeability of the intestinal epithelial barrier is regulated in response to physiological and pathophysiological stimuli. Recent work has characterized a critical role of acute tight junction regulation in diarrhea secondary to T cell activation and cytokine release. The intracellular mediators of the ensuing barrier dysfunction include myosin light chain kinase, which phosphorylates myosin I...